Structural Basis for Modulation of Gating Property of G Protein-gated Inwardly Rectifying Potassium Ion Channel (GIRK) by i/o-family G Protein α Subunit (Gα(i/o))

G protein-gated inwardly rectifying potassium channel (GIRK) plays a crucial role in regulating heart rate and neuronal excitability. The gating of GIRK is regulated by the association and dissociation of G protein βγ subunits (Gβγ), which are released from pertussis toxin-sensitive G protein α subu...

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Bibliographic Details
Main Authors: Mase, Yoko, Yokogawa, Mariko, Osawa, Masanori, Shimada, Ichio
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365990/
https://ncbi.nlm.nih.gov/pubmed/22511772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.353888
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