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Selective Degradation of CDK6 by a Palbociclib Based PROTAC
Development of selective kinase inhibitors that target the ATP binding site continues to be a challenge largely due to similar binding pockets. Palbociclib is a cyclin-dependent kinase inhibitor that targets the ATP binding site of CDK4 and CDK6 with similar potency. The enzymatic function associate...
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6487213/ https://ncbi.nlm.nih.gov/pubmed/30935795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.03.035 |
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