BETP degradation simultaneously targets acute myelogenous leukemic stem cells and the microenvironment

The antileukemic effect of inhibiting bromodomain and extra-terminal domain-containing (BET-containing) proteins (BETPs) such as BRD4 has largely been largely attributed to transcriptional downregulation of cellular anabolic and antiapoptotic processes, but its effect on the bone marrow microenviron...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Piya, Sujan, Mu, Hong, Bhattacharya, Seemana, Lorenzi, Philip L., Davis, R. Eric, McQueen, Teresa, Ruvolo, Vivian, Baran, Natalia, Wang, Zhiqiang, Qian, Yimin, Crews, Craig M., Konopleva, Marina, Ishizawa, Jo, You, M. James, Kantarjian, Hagop, Andreeff, Michael, Borthakur, Gautam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486356/
https://ncbi.nlm.nih.gov/pubmed/30829648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120654
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