Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

Autophagy is a cellular adaptive mechanism to stress, including that induced by chemotherapeutic agents. Reverse phase protein array suggested that high expression of the essential autophagy-related protein, Atg7, was associated with shorter remission in newly diagnosed acute myeloid leukemia (AML)...

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Pubblicato in:Blood
Autori principali: Piya, Sujan, Kornblau, Steven M., Ruvolo, Vivian R., Mu, Hong, Ruvolo, Peter P., McQueen, Teresa, Davis, R. Eric, Hail, Numsen, Kantarjian, Hagop, Andreeff, Michael, Borthakur, Gautam
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009514/
https://ncbi.nlm.nih.gov/pubmed/27268264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-692244
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