Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance

Leukemia cells are protected from chemotherapy-induced apoptosis by their interactions with bone marrow mesenchymal stromal cells (BM-MSCs). Yet the underlying mechanisms associated with this protective effect remain unclear. Genome-wide gene expression profiling of BM-MSCs revealed that coculture w...

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Autori principali: Jacamo, Rodrigo, Chen, Ye, Wang, Zhiqiang, Ma, Wencai, Zhang, Min, Spaeth, Erika L., Wang, Ying, Battula, Venkata L., Mak, Po Yee, Schallmoser, Katharina, Ruvolo, Peter, Schober, Wendy D., Shpall, Elizabeth J., Nguyen, Martin H., Strunk, Dirk, Bueso-Ramos, Carlos E., Konoplev, Sergej, Davis, R. Eric, Konopleva, Marina, Andreeff, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999754/
https://ncbi.nlm.nih.gov/pubmed/24599548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-511527
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