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Activation of p53 signaling by MI-63 induces apoptosis in acute myelogenous leukemia cells
Non-mutational inactivation of p53 is frequent in acute myeloid leukemia (AML) via overexpression of MDM2. We report that treatment with MI-63, a novel inhibitor of MDM2, activates p53 signaling to induce apoptosis in AML cell lines and primary samples. Cell lines naturally devoid of p53 or expressi...
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| Glavni autori: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4122268/ https://ncbi.nlm.nih.gov/pubmed/20423286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428191003731325 |
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