Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

The traditional view is that cancer cells predominately produce ATP by glycolysis, rather than by oxidation of energy-providing substrates. Mitochondrial uncoupling — the continuing reduction of oxygen without ATP synthesis — has recently been shown in leukemia cells to circumvent the ability of oxy...

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Detalhes bibliográficos
Main Authors: Samudio, Ismael, Harmancey, Romain, Fiegl, Michael, Kantarjian, Hagop, Konopleva, Marina, Korchin, Borys, Kaluarachchi, Kumar, Bornmann, William, Duvvuri, Seshagiri, Taegtmeyer, Heinrich, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799198/
https://ncbi.nlm.nih.gov/pubmed/20038799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38942
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