Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

The traditional view is that cancer cells predominately produce ATP by glycolysis, rather than by oxidation of energy-providing substrates. Mitochondrial uncoupling — the continuing reduction of oxygen without ATP synthesis — has recently been shown in leukemia cells to circumvent the ability of oxy...

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מידע ביבליוגרפי
Main Authors: Samudio, Ismael, Harmancey, Romain, Fiegl, Michael, Kantarjian, Hagop, Konopleva, Marina, Korchin, Borys, Kaluarachchi, Kumar, Bornmann, William, Duvvuri, Seshagiri, Taegtmeyer, Heinrich, Andreeff, Michael
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2009
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799198/
https://ncbi.nlm.nih.gov/pubmed/20038799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38942
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