Inhibition of mitochondrial metabolism by Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate induces apoptotic or autophagic cell death in chronic myelogenous leukemia cells

The initial success of the first synthetic bcr-abl kinase inhibitor imatinib has been dampened by the emergence of imatinib-resistant disease in blast crisis CML. Here we report that the novel triterpenoid methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me) potently induced cytotoxicity in im...

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Autori principali: Samudio, Ismael, Kurinna, Svitlana, Ruvolo, Peter, Korchin, Borys, Kantarjian, Hagop, Beran, Miloslav, Dunner, Kenneth, Kondo, Seiji, Andreeff, Michael, Konopleva, Marina
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396196/
https://ncbi.nlm.nih.gov/pubmed/18483301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-0553
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