Loading...
Inhibition of mitochondrial metabolism by Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate induces apoptotic or autophagic cell death in chronic myelogenous leukemia cells
The initial success of the first synthetic bcr-abl kinase inhibitor imatinib has been dampened by the emergence of imatinib-resistant disease in blast crisis CML. Here we report that the novel triterpenoid methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me) potently induced cytotoxicity in im...
Na minha lista:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396196/ https://ncbi.nlm.nih.gov/pubmed/18483301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-0553 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|