The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr(db/db) Mice

The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid (CDDO) and its methyl ester (CDDO-Me) are undergoing clinical trials in cancer and leukemia therapy. Here we report that CDDO-Me ameliorates diabetes in high fat diet-fed type 2 diabetic mice and in Lepr(db/db) mice. CDDO-Me reduces proi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Saha, Pradip K., Reddy, Vasumathi T., Konopleva, Marina, Andreeff, Michael, Chan, Lawrence
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2010
Aiheet:
Metabolism
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003357/
https://ncbi.nlm.nih.gov/pubmed/20956520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176545
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia