The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr(db/db) Mice

The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid (CDDO) and its methyl ester (CDDO-Me) are undergoing clinical trials in cancer and leukemia therapy. Here we report that CDDO-Me ameliorates diabetes in high fat diet-fed type 2 diabetic mice and in Lepr(db/db) mice. CDDO-Me reduces proi...

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Bibliographic Details
Main Authors: Saha, Pradip K., Reddy, Vasumathi T., Konopleva, Marina, Andreeff, Michael, Chan, Lawrence
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003357/
https://ncbi.nlm.nih.gov/pubmed/20956520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176545
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