Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice

The C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me), one of the synthetic triterpenoids, has been found to have potent anti-inflammatory and anticancer properties in vitro and in vivo. However, its usefulness in mitigating radiation-induced lung injury (RILI), including r...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Wang, Yan-Yang, Zhang, Cui-Ying, Ma, Ya-Qiong, He, Zhi-Xu, Zhe, Hong, Zhou, Shu-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482372/
https://ncbi.nlm.nih.gov/pubmed/26124639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S80958
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