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Phase I Study of the Synthetic Triterpenoid, 2-Cyano-3, 12-Dioxoolean-1, 9-Dien-28-Oic Acid (CDDO), in Advanced Solid Tumors
BACKGROUND: The triterpenoid 2-Cyano-3, 12-Dioxoolean-1, 9-Dien-28-Oic Acid (CDDO, previously RTA-401) is a multifunctional molecule that controls cellular growth and differentiation. It is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ) and induci...
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| Publicado no: | Cancer Chemother Pharmacol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4490274/ https://ncbi.nlm.nih.gov/pubmed/21805353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1712-y |
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