Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

The traditional view is that cancer cells predominately produce ATP by glycolysis, rather than by oxidation of energy-providing substrates. Mitochondrial uncoupling — the continuing reduction of oxygen without ATP synthesis — has recently been shown in leukemia cells to circumvent the ability of oxy...

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Autores principales: Samudio, Ismael, Harmancey, Romain, Fiegl, Michael, Kantarjian, Hagop, Konopleva, Marina, Korchin, Borys, Kaluarachchi, Kumar, Bornmann, William, Duvvuri, Seshagiri, Taegtmeyer, Heinrich, Andreeff, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799198/
https://ncbi.nlm.nih.gov/pubmed/20038799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38942
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