Mechanisms of antileukemic activity of the novel BH3 mimetic GX15-070 (obatoclax)

In this study, we investigated the mechanism of apoptosis induction of obatoclax (GX15-070), a novel BH3 mimetic, in acute myeloid leukemia (AML) cell lines and primary AML samples. Obatoclax inhibited cell growth of HL-60, U937, OCI-AML3 and KG-1 cell lines. Apoptosis induction contributed to the o...

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Hauptverfasser: Konopleva, Marina, Watt, Julie, Contractor, Rooha, Tsao, Twee, Harris, David, Estrov, Zeev, Bornmann, William, Kantarjian, Hagop, Viallet, Jean, Samudio, Ismael, Andreeff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096127/
https://ncbi.nlm.nih.gov/pubmed/18451169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1919
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