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Mechanisms of antileukemic activity of the novel BH3 mimetic GX15-070 (obatoclax)
In this study, we investigated the mechanism of apoptosis induction of obatoclax (GX15-070), a novel BH3 mimetic, in acute myeloid leukemia (AML) cell lines and primary AML samples. Obatoclax inhibited cell growth of HL-60, U937, OCI-AML3 and KG-1 cell lines. Apoptosis induction contributed to the o...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096127/ https://ncbi.nlm.nih.gov/pubmed/18451169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1919 |
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