Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

Obatoclax (GX15-070), a small-molecule inhibitor of antiapoptotic Bcl-2 proteins, has been reported to trigger cell death via autophagy. However, the underlying molecular mechanisms have remained elusive. Here, we identify GX15-070-stimulated assembly of the necrosome on autophagosomal membranes as...

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Detalhes bibliográficos
Main Authors: Basit, F, Cristofanon, S, Fulda, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741498/
https://ncbi.nlm.nih.gov/pubmed/23744296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.45
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