GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D and L mediated autophagosomal lysis in antiestrogen resistant breast cancer cells

In estrogen receptor positive (ER+) breast cancer cells, BCL2 overexpression contributes to antiestrogen resistance. Direct targeting of the antiapoptotic BCL2 members with GX15-070 (GX; obatoclax), a BH3-mimetic currently in clinical development, is an attractive strategy to overcome antiestrogen r...

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Autori principali: Schwartz-Roberts, Jessica L., Shajahan, Ayesha N., Cook, Katherine L., Wärri, Anni, Abu-Asab, Mones, Clarke, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624027/
https://ncbi.nlm.nih.gov/pubmed/23395885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0617
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