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BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells
We have previously reported overexpression of antiapoptotic MCL-1 protein in human oral cancers and its association with therapy resistance and poor prognosis, implying it to be a potential therapeutic target. Hence, we investigated the efficacy and mechanism of action of Obatoclax, a BH3 mimetic pa...
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| Published in: | Oncotarget |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Impact Journals LLC
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5601122/ https://ncbi.nlm.nih.gov/pubmed/28947954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11085 |
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