Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

Elevated expression of members of the BCL-2 pro-survival family of proteins can confer resistance to apoptosis in cancer cells. Small molecule obatoclax (GX15-070), which is predicted to occupy a hydrophobic pocket within the BH3 binding groove of BCL-2, antagonizes these members and induces apoptos...

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Hlavní autoři: Nguyen, Mai, Marcellus, Richard C., Roulston, Anne, Watson, Mark, Serfass, Lucile, Murthy Madiraju, S. R., Goulet, Daniel, Viallet, Jean, Bélec, Laurent, Billot, Xavier, Acoca, Stephane, Purisima, Enrico, Wiegmans, Adrian, Cluse, Leonie, Johnstone, Ricky W., Beauparlant, Pierre, Shore, Gordon C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148320/
https://ncbi.nlm.nih.gov/pubmed/18040043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709443104
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