Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis

The pan Bcl-2 family antagonist Obatoclax (GX15-070), currently in clinical trials, was shown to sensitize TRAIL-resistant tumors to TRAIL-mediated apoptosis via the release of Bak and Bim from Mcl-1 or Bcl-2/Bcl-X(L) complexes or by the activation of Bax, though other mechanisms were not examined....

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Autori principali: Martínez-Paniagua, Melisa A, Baritaki, Stavroula, Huerta-Yepez, Sara, Ortiz-Navarrete, Vianney F, González-Bonilla, Cesar, Bonavida, Benjamin, Vega, Mario I
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233494/
https://ncbi.nlm.nih.gov/pubmed/21822052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.16.16952
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