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THE COMBINATION OF A HISTONE DEACETYLASE INHIBITOR WITH THE BH3-MIMETIC GX15-070 HAS SYNERGISTIC ANTILEUKEMIA ACTIVITY BY ACTIVATING BOTH APOPTOTSIS AND AUTOPHAGY
PURPOSE: Single agent histone deacetylase inhibitors (HDACi) have limited clinical activity in human leukemia. Although the way HDACi exert their antileukemia effect is not fully understood, it is accepted that induction of apoptosis is important. We hypothesized therefore that combination of an HDA...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4113507/ https://ncbi.nlm.nih.gov/pubmed/20538760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0032 |
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