Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor

We studied the cellular and molecular effects of the combination of an anthracycline with 2 different histone deacetylase inhibitors (HDACIs): vorinostat (suberoylanilide hydroxamic acid) and valproic acid (VPA). The 10% inhibitory concentration (IC(10)) of idarubicin was 0.5 nM in MOLT4 and 1.5 nM...

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Autors principals: Sanchez-Gonzalez, Blanca, Yang, Hui, Bueso-Ramos, Carlos, Hoshino, Koyu, Quintas-Cardama, Alfonso, Richon, Victoria M., Garcia-Manero, Guillermo
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2006
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895868/
https://ncbi.nlm.nih.gov/pubmed/16675713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-09-008086
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