BETP degradation simultaneously targets acute myelogenous leukemic stem cells and the microenvironment

The antileukemic effect of inhibiting bromodomain and extra-terminal domain-containing (BET-containing) proteins (BETPs) such as BRD4 has largely been largely attributed to transcriptional downregulation of cellular anabolic and antiapoptotic processes, but its effect on the bone marrow microenviron...

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Pubblicato in:J Clin Invest
Autori principali: Piya, Sujan, Mu, Hong, Bhattacharya, Seemana, Lorenzi, Philip L., Davis, R. Eric, McQueen, Teresa, Ruvolo, Vivian, Baran, Natalia, Wang, Zhiqiang, Qian, Yimin, Crews, Craig M., Konopleva, Marina, Ishizawa, Jo, You, M. James, Kantarjian, Hagop, Andreeff, Michael, Borthakur, Gautam
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486356/
https://ncbi.nlm.nih.gov/pubmed/30829648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120654
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