A chemical toolbox for the study of bromodomains and epigenetic signaling

Bromodomains (BRDs) are conserved protein interaction modules which recognize (read) acetyl-lysine modifications, however their role(s) in regulating cellular states and their potential as targets for the development of targeted treatment strategies is poorly understood. Here we present a set of 25...

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Udgivet i:Nat Commun
Main Authors: Wu, Qin, Heidenreich, David, Zhou, Stanley, Ackloo, Suzanne, Krämer, Andreas, Nakka, Kiran, Lima-Fernandes, Evelyne, Deblois, Genevieve, Duan, Shili, Vellanki, Ravi N., Li, Fengling, Vedadi, Masoud, Dilworth, Jeffrey, Lupien, Mathieu, Brennan, Paul E., Arrowsmith, Cheryl H., Müller, Susanne, Fedorov, Oleg, Filippakopoulos, Panagis, Knapp, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478789/
https://ncbi.nlm.nih.gov/pubmed/31015424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09672-2
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