DIPG-11. ACTIVATION OF RAS SIGNALING AND DISTINCT MITOGEN-ACTIVATED PROTEIN KINASES (MAPKs) PROVIDES UNIQUE THERAPEUTIC VULNERABILITIES IN MUTANT HISTONE DIPG

Diffuse intrinsic pontine gliomas (DIPGs) are incurable pediatric brain tumors with an aggressive onset. Apart from irradiation, there are currently no effective therapies available for DIPG patients, who have a median survival time of less than one year. DIPG cells possess a mutation in histone H3...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Koncar, Robert, Stanton, Ann-Catherine, Dey, Brittany, Agrawal, Nishant, Wassell, Michelle, McCarl, Lauren, Locke, Abigail, Sanders, Lauren, Vaske, Olena Morozova, Kohanbash, Gary, Felker, James, James, C David, Hashizume, Rintaro, Broniscer, Alberto, Pollack, Ian, Agnihotri, Sameer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Diffuse Intrinsic Pontine Glioma (DIPG)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477254/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.032
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