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DIPG-47. HISTONE MUTATIONS ENHANCE RAS MEDIATED ERK5 GROWTH SIGNALING IN DIFFUSE MIDLINE GLIOMAS

Diffuse midline gliomas (DMGs) are incurable brain tumors with an aggressive onset. Apart from irradiation, there are currently no effective therapies available for patients with DMG, who have a median survival time of less than one year. Most DMG cells harbor mutations in genes encoding histone H3...

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Publicado en:Neuro Oncol
Main Authors: Stanton, Ann-Catherine, Koncar, Robert, Golbourn, Brian, Dey, Brittany, Agrawal, Nishant, Mack, Stephen, Pollack, Ian, Agnihotri, Sameer
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715289/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.093
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