DIPG-11. ACTIVATION OF RAS SIGNALING AND DISTINCT MITOGEN-ACTIVATED PROTEIN KINASES (MAPKs) PROVIDES UNIQUE THERAPEUTIC VULNERABILITIES IN MUTANT HISTONE DIPG

Diffuse intrinsic pontine gliomas (DIPGs) are incurable pediatric brain tumors with an aggressive onset. Apart from irradiation, there are currently no effective therapies available for DIPG patients, who have a median survival time of less than one year. DIPG cells possess a mutation in histone H3...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Koncar, Robert, Stanton, Ann-Catherine, Dey, Brittany, Agrawal, Nishant, Wassell, Michelle, McCarl, Lauren, Locke, Abigail, Sanders, Lauren, Vaske, Olena Morozova, Kohanbash, Gary, Felker, James, James, C David, Hashizume, Rintaro, Broniscer, Alberto, Pollack, Ian, Agnihotri, Sameer
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Diffuse Intrinsic Pontine Glioma (DIPG)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477254/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.032
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