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DIPG-22. GENETIC MODELING IMPLICATES RAS AND MYC AS KEY EPIGENETICALLY ACTIVATED TRANSCRIPTIONAL TARGETS OF H3K27M-DRIVEN CANCER
Histone 3 mutations at lysine 27 (H3K27M) are frequent drivers of midline gliomagenesis, occurring in ~80% of diffuse intrinsic pontine gliomas (DIPG) and leading to widespread H3K27me3 changes through PRC2 inhibition. Although H3K27M mutations appear to cooperate with additional mutations including...
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| Publicado en: | Neuro Oncol |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477253/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.043 |
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