DIPG-22. GENETIC MODELING IMPLICATES RAS AND MYC AS KEY EPIGENETICALLY ACTIVATED TRANSCRIPTIONAL TARGETS OF H3K27M-DRIVEN CANCER

Histone 3 mutations at lysine 27 (H3K27M) are frequent drivers of midline gliomagenesis, occurring in ~80% of diffuse intrinsic pontine gliomas (DIPG) and leading to widespread H3K27me3 changes through PRC2 inhibition. Although H3K27M mutations appear to cooperate with additional mutations including...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Siddaway, Robert, Pajovic, Sanja, Kim, Byungjin, Ryall, Scott, Agnihotri, Sameer, Li, Christopher, Hawkins, Cynthia
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Diffuse Intrinsic Pontine Glioma (DIPG)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477253/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.043
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