DIPG-31. MOLECULAR MECHANISMS AND FUNCTIONAL IMPACT OF ABERRANT SPLICING IN DIFFUSE MIDLINE GLIOMAS

Fewer than 1% of children diagnosed with diffuse-midline glioma (DMG) survive for more than 5 years, because no effective therapies exist for these patients. Here, we sought to identify and characterize mechanisms of aberrant splicing (AS) in primary DMG tumors. We observed transcriptome-wide AS (9,...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Naqvi, Ammar, Gaonkar, Krutika, Zhu, Yuankun, Brown, Miguel, Zhang, Bo, Ennis, Brian, Storm, Phillip, Resnick, Adam, Rokita, Jo Lynne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Diffuse Midline Glioma/DIPG
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715771/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.079
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