Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes

Despite our extensive knowledge on the biology of protein kinase C (PKC) and its involvement in disease, limited success has been attained in the generation of PKC isozyme-specific modulators acting via the C1 domain, the binding site for the lipid second messenger diacylglycerol (DAG) and the phorb...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Cooke, Mariana, Casado-Medrano, Victoria, Ann, Jihyae, Lee, Jeewoo, Blumberg, Peter M., Abba, Martin C., Kazanietz, Marcelo G.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465381/
https://ncbi.nlm.nih.gov/pubmed/30988374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42581-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items