Characterization of AJH-836, a diacylglycerol-lactone with selectivity for novel PKC isozymes

Diacylglycerol (DAG) is a key lipid second messenger downstream of cellular receptors that binds to the C1 domain in many regulatory proteins. Protein kinase C (PKC) isoforms constitute the most prominent family of signaling proteins with DAG-responsive C1 domains, but six other families of proteins...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Cooke, Mariana, Zhou, Xiaoling, Casado-Medrano, Victoria, Lopez-Haber, Cynthia, Baker, Martin J., Garg, Rachana, Ann, Jihyae, Lee, Jeewoo, Blumberg, Peter M., Kazanietz, Marcelo G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986226/
https://ncbi.nlm.nih.gov/pubmed/29636415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000235
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