Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.

The bryostatins are macrocyclic lactones that represent an additional structural class of potent activators of protein kinase C. These marine animal biosynthetic products are of unusual interest because they induce only a subset of the biological responses induced by the phorbol esters. We have now...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wender, P A, Cribbs, C M, Koehler, K F, Sharkey, N A, Herald, C L, Kamano, Y, Pettit, G R, Blumberg, P M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282151/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3174627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.19.7197
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