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Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
The clinical impact of drug-drug interactions based on time-dependent inhibition of cytochrome P450 (CYP) 3A4 has often been overpredicted, likely due to use of improper inhibitor concentration estimates at the enzyme. Here, we investigated if use of cytosolic unbound inhibitor concentrations could...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6458156/ https://ncbi.nlm.nih.gov/pubmed/30971754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42051-x |
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