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Improved Predictions of Drug–Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A
Time-dependent inactivation (TDI) of cytochrome P450s (CYPs) is a leading cause of clinical drug–drug interactions (DDIs). Current methods tend to overpredict DDIs. In this study, a numerical approach was used to model complex CYP3A TDI in human-liver microsomes. The inhibitors evaluated included tr...
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| Publicado no: | Mol Pharm |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5938745/ https://ncbi.nlm.nih.gov/pubmed/29608318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00129 |
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