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Improved Predictions of Drug–Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A

Time-dependent inactivation (TDI) of cytochrome P450s (CYPs) is a leading cause of clinical drug–drug interactions (DDIs). Current methods tend to overpredict DDIs. In this study, a numerical approach was used to model complex CYP3A TDI in human-liver microsomes. The inhibitors evaluated included tr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Pharm
Main Authors: Yadav, Jaydeep, Korzekwa, Ken, Nagar, Swati
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938745/
https://ncbi.nlm.nih.gov/pubmed/29608318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00129
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