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Mechanism-based Inhibition of CYP3A4 by Podophyllotoxin: Aging of an Intermediate is Important for in Vitro/in Vivo Correlations
An in vitro observation of time-dependent-inhibition of metabolic enzymes often results in removing a potential drug from the drug-pipeline. However, the accepted method for predicting TDIs of the important drug metabolizing cytochrome P450 enzymes often overestimates the drug interaction potential....
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| Publicado no: | Mol Pharm |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5059843/ https://ncbi.nlm.nih.gov/pubmed/27336918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.6b00436 |
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