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Drug Distribution. Part 1. Models to Predict Membrane Partitioning
PURPOSE: Tissue partitioning is an important component of drug distribution and half-life. Protein binding and lipid partitioning together determine drug distribution. METHODS: Two structure-based models to predict partitioning into microsomal membranes are presented. An orientation-based model was...
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| Publicado no: | Pharm Res |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5588161/ https://ncbi.nlm.nih.gov/pubmed/27981450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-2085-z |
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