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Drug Distribution Part 2. Predicting Volume of Distribution from Plasma Protein Binding and Membrane Partitioning

PURPOSE: Volume of distribution is an important pharmacokinetic parameter in the distribution and half-life of a drug. Protein binding and lipid partitioning together determine drug distribution. METHODS: Here we present a simple relationship that estimates the volume of distribution with the fracti...

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書目詳細資料
發表在:Pharm Res
Main Authors: Korzekwa, Ken, Nagar, Swati
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5285473/
https://ncbi.nlm.nih.gov/pubmed/27966088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-2086-y
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