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Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions

Drug distribution is a necessary component of models to predict human pharmacokinetics. A new membrane-based tissue-plasma partition coefficient (K(p)) method (K(p,mem)) to predict unbound tissue to plasma partition coefficients (K(pu)) was developed using in vitro membrane partitioning [fraction un...

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Vydáno v:Drug Metab Dispos
Hlavní autoři: Holt, Kimberly, Ye, Min, Nagar, Swati, Korzekwa, Ken
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750188/
https://ncbi.nlm.nih.gov/pubmed/31324699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.087973
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