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Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions
Drug distribution is a necessary component of models to predict human pharmacokinetics. A new membrane-based tissue-plasma partition coefficient (K(p)) method (K(p,mem)) to predict unbound tissue to plasma partition coefficients (K(pu)) was developed using in vitro membrane partitioning [fraction un...
Kaydedildi:
| Yayımlandı: | Drug Metab Dispos |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6750188/ https://ncbi.nlm.nih.gov/pubmed/31324699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.087973 |
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