ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

Lysyl oxidase (LOX) and LOX-like (LOXL) proteins are copper-dependent metalloenzymes with well-documented roles in tumor metastasis and fibrotic diseases. The mechanism by which copper is delivered to these enzymes is poorly understood. In this study, we demonstrate that the copper transporter ATP7A...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Shanbhag, Vinit, Jasmer-McDonald, Kimberly, Zhu, Sha, Martin, Adam L., Gudekar, Nikita, Khan, Aslam, Ladomersky, Erik, Singh, Kamlendra, Weisman, Gary A., Petris, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452744/
https://ncbi.nlm.nih.gov/pubmed/30890638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817473116
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