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Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess

Copper (Cu) is an essential, yet potentially toxic nutrient, as illustrated by inherited diseases of copper deficiency and excess. Elevated expression of the ATP7A Cu exporter is known to confer copper tolerance, however, the contribution of metal-binding metallothioneins is less clear. In this stud...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Gudekar, Nikita, Shanbhag, Vinit, Wang, Yanfang, Ralle, Martina, Weisman, Gary A., Petris, Michael J.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217913/
https://ncbi.nlm.nih.gov/pubmed/32398691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64521-3
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