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Multiple di-leucines in the ATP7A copper transporter are required for retrograde trafficking to the trans-Golgi network

The ATP7A protein is a ubiquitous copper-transporting P-type ATPase that is mutated in the lethal pediatric disorder of copper metabolism, Menkes disease. The steady-state location of ATP7A is within the trans-Golgi network (TGN), where it delivers copper to copper-dependent enzymes within the secre...

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Vydáno v:Metallomics
Hlavní autoři: Zhu, Sha, Shanbhag, Vinit, Hodgkinson, Victoria L., Petris, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025395/
https://ncbi.nlm.nih.gov/pubmed/27337370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6mt00093b
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