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Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking

ATP7A and ATP7B are copper-transporting P-type ATPases that are essential to eukaryotic copper homeostasis and must traffic between intracellular compartments to carry out their functions. Previously, we identified a nine-amino acid sequence (F37–E45) in the NH(2) terminus of ATP7B that is required...

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Main Authors: Braiterman, L., Nyasae, L., Leves, F., Hubbard, A. L.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Physiological Society 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129927/
https://ncbi.nlm.nih.gov/pubmed/21454443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00038.2011
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