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Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B
ATP7B is a copper-transporting P-type ATPase present predominantly in liver. In basal copper, hepatic ATP7B is in a post-trans-Golgi network (TGN) compartment where it loads cytoplasmic Cu(I) onto newly synthesized ceruloplasmin. When copper levels rise, the protein redistributes via unique vesicles...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643914/ https://ncbi.nlm.nih.gov/pubmed/19033537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90489.2008 |
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