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Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B

ATP7B is a copper-transporting P-type ATPase present predominantly in liver. In basal copper, hepatic ATP7B is in a post-trans-Golgi network (TGN) compartment where it loads cytoplasmic Cu(I) onto newly synthesized ceruloplasmin. When copper levels rise, the protein redistributes via unique vesicles...

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Sonraí Bibleagrafaíochta
Main Authors: Braiterman, Lelita, Nyasae, Lydia, Guo, Yan, Bustos, Rodrigo, Lutsenko, Svetlana, Hubbard, Ann
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643914/
https://ncbi.nlm.nih.gov/pubmed/19033537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90489.2008
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