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ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis
Lysyl oxidase (LOX) and LOX-like (LOXL) proteins are copper-dependent metalloenzymes with well-documented roles in tumor metastasis and fibrotic diseases. The mechanism by which copper is delivered to these enzymes is poorly understood. In this study, we demonstrate that the copper transporter ATP7A...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6452744/ https://ncbi.nlm.nih.gov/pubmed/30890638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817473116 |
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