ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

Lysyl oxidase (LOX) and LOX-like (LOXL) proteins are copper-dependent metalloenzymes with well-documented roles in tumor metastasis and fibrotic diseases. The mechanism by which copper is delivered to these enzymes is poorly understood. In this study, we demonstrate that the copper transporter ATP7A...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Shanbhag, Vinit, Jasmer-McDonald, Kimberly, Zhu, Sha, Martin, Adam L., Gudekar, Nikita, Khan, Aslam, Ladomersky, Erik, Singh, Kamlendra, Weisman, Gary A., Petris, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452744/
https://ncbi.nlm.nih.gov/pubmed/30890638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817473116
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