ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

Lysyl oxidase (LOX) and LOX-like (LOXL) proteins are copper-dependent metalloenzymes with well-documented roles in tumor metastasis and fibrotic diseases. The mechanism by which copper is delivered to these enzymes is poorly understood. In this study, we demonstrate that the copper transporter ATP7A...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Shanbhag, Vinit, Jasmer-McDonald, Kimberly, Zhu, Sha, Martin, Adam L., Gudekar, Nikita, Khan, Aslam, Ladomersky, Erik, Singh, Kamlendra, Weisman, Gary A., Petris, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452744/
https://ncbi.nlm.nih.gov/pubmed/30890638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817473116
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