Structural and mechanistic insights into mechanoactivation of focal adhesion kinase

Focal adhesion kinase (FAK) is a key signaling molecule regulating cell adhesion, migration, and survival. FAK localizes into focal adhesion complexes formed at the cytoplasmic side of cell attachment to the ECM and is activated after force generation via actomyosin fibers attached to this complex....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Bauer, Magnus Sebastian, Baumann, Fabian, Daday, Csaba, Redondo, Pilar, Durner, Ellis, Jobst, Markus Andreas, Milles, Lukas Frederik, Mercadante, Davide, Pippig, Diana Angela, Gaub, Hermann Eduard, Gräter, Frauke, Lietha, Daniel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2019
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452671/
https://ncbi.nlm.nih.gov/pubmed/30877242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820567116
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