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Allosteric Regulation of Focal Adhesion Kinase by PIP(2) and ATP
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that regulates cell signaling, proliferation, migration, and development. A major mechanism of regulation of FAK activity is an intramolecular autoinhibitory interaction between two of its domains—the catalytic and FERM domains. Upon cell...
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| Udgivet i: | Biophys J |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4317530/ https://ncbi.nlm.nih.gov/pubmed/25650936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.11.3454 |
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