Mechanism of Focal Adhesion Kinase Mechanosensing

Mechanosensing at focal adhesions regulates vital cellular processes. Here, we present results from molecular dynamics (MD) and mechano-biochemical network simulations that suggest a direct role of Focal Adhesion Kinase (FAK) as a mechano-sensor. Tensile forces, propagating from the membrane through...

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Publicat a:PLoS Comput Biol
Autors principals: Zhou, Jing, Aponte-Santamaría, Camilo, Sturm, Sebastian, Bullerjahn, Jakob Tómas, Bronowska, Agnieszka, Gräter, Frauke
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636223/
https://ncbi.nlm.nih.gov/pubmed/26544178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004593
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