Structural and mechanistic insights into mechanoactivation of focal adhesion kinase

Focal adhesion kinase (FAK) is a key signaling molecule regulating cell adhesion, migration, and survival. FAK localizes into focal adhesion complexes formed at the cytoplasmic side of cell attachment to the ECM and is activated after force generation via actomyosin fibers attached to this complex....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bauer, Magnus Sebastian, Baumann, Fabian, Daday, Csaba, Redondo, Pilar, Durner, Ellis, Jobst, Markus Andreas, Milles, Lukas Frederik, Mercadante, Davide, Pippig, Diana Angela, Gaub, Hermann Eduard, Gräter, Frauke, Lietha, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452671/
https://ncbi.nlm.nih.gov/pubmed/30877242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820567116
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